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Journal of Virology, January 2007, p. 411-415, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.01825-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Disseminated Simian Varicella Virus Infection in an Irradiated Rhesus Macaque (Macaca mulatta){triangledown}

Krishnan Kolappaswamy,1,2,6 Ravi Mahalingam,3 Vicki Traina-Dorge,7 Steven T. Shipley,1,2 Donald H. Gilden,3,4* Bette K. Kleinschmidt-Demasters,3,5 Charles G. McLeod Jr.,1 Laura L. Hungerford,6 and Louis J. DeTolla1,2,6

Program of Comparative Medicine,1 Departments of Pathology,2 Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, 21201; Departments of,6 Neurology,3 Microbiology,4 Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262,5 Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 704337

Received 21 August 2006/ Accepted 27 September 2006

We describe correlative clinicopathological/virological findings from a simian varicella virus (SVV)-seronegative monkey that developed disseminated varicella 105 days after gamma-irradiation. Twelve other monkeys in the colony were also irradiated, none of which developed varicella. Before irradiation, sera from the monkey that developed disseminated infection and one asymptomatic monkey were available. Analysis indicated that subclinical reactivation of latent SVV from an asymptomatic irradiated monkey likely led to disseminated varicella in the seronegative irradiated monkey. These findings parallel those from humans with disseminated varicella infection and support the usefulness of SVV infection as a model for human varicella-zoster virus infection, particularly virus reactivation after gamma-irradiation.

* Corresponding author. Mailing address: Department of Neurology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Mail Stop B182, Denver, CO 80262. Phone: (303) 315-8281. Fax: (303) 315-8720. E-mail: don.gilden{at}uchsc.edu.

{triangledown} Published ahead of print on 1 November 2006.

Journal of Virology, January 2007, p. 411-415, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.01825-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mueller, N. H., Graf, L. L., Orlicky, D., Gilden, D., Cohrs, R. J. (2009). Phosphorylation of the Nuclear Form of Varicella-Zoster Virus Immediate-Early Protein 63 by Casein Kinase II at Serine 186. J. Virol. 83: 12094-12100 [Abstract] [Full Text]  


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