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Journal of Virology, April 2006, p. 4200-4202, Vol. 80, No. 8
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.8.4200-4202.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Murine Cytomegalovirus Interference with Antigen Presentation Contributes to the Inability of CD8 T Cells To Control Virus in the Salivary Gland

Xiuju Lu, Amelia K. Pinto, Ann M. Kelly, Kathy S. Cho, and Ann B. Hill*

Department of Molecular Microbiology and Immunology, L220, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon

Received 22 September 2005/ Accepted 2 February 2006

Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivary gland is uniquely resistant to CD8 T-cell control. The contribution of viral genes that interfere with antigen presentation (VIPRs) to this resistance was assessed using a mutant lacking MCMV's known VIPRs. Salivary gland titers of the VIPR-deficient virus were at least 10-fold lower than those of the wild type during the persistent phase of infection; the defect was reversed by depleting CD8 T cells. Thus, VIPRs contribute to CD8 T cells' inability to control virus in the salivary gland.

* Corresponding author. Mailing address: Department of Molecular Microbiology and Immunology, L220, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239. Phone: (503) 494-0763. Fax: (503) 494-6862. E-mail: hillan{at}ohsu.edu.

Journal of Virology, April 2006, p. 4200-4202, Vol. 80, No. 8
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.8.4200-4202.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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