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Journal of Virology, April 2006, p. 4191-4195, Vol. 80, No. 8
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.8.4191-4195.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Cellular Factors Required for Lassa Virus Budding

Shuzo Urata,1,2,3 Takeshi Noda,2,4 Yoshihiro Kawaoka,2,4,5 Hideyoshi Yokosawa,3 and Jiro Yasuda1,2*

First Department of Forensic Science, National Research Institute of Police Science, Kashiwa 277-0882, Japan,1 CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan,2 Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan,3 International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan,4 Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin 537065

Received 28 December 2005/ Accepted 23 January 2006

It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z protein efficiently produces VLPs and uses cellular factors, Vps4A, Vps4B, and Tsg101, in budding, suggesting that Lassa virus budding uses the multivesicular body pathway functionally. Our data may provide a clue to develop an effective antiviral strategy for Lassa virus.

* Corresponding author. Mailing address: First Department of Forensic Science, National Research Institute of Police Science, Kashiwa 277-0882, Japan. Phone: 81-4-7135-8001. Fax: 81-4-7133-9159. E-mail: yasuda{at}nrips.go.jp.

Journal of Virology, April 2006, p. 4191-4195, Vol. 80, No. 8
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.8.4191-4195.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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