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Journal of Virology, April 2006, p. 4183-4186, Vol. 80, No. 8
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.8.4183-4186.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Maternally Derived Recombinant Human Anti-Hantavirus Monoclonal Antibodies Are Transferred to Mouse Offspring during Lactation and Neutralize Virus In Vitro

Shuyang Yu,1 Mifang Liang,2 BaoLiang Fan,3 Hongtao Xu,1 Chuan Li,2 Quanfu Zhang,2 Dexin Li,2 Bo Tang,1 Shijie Li,1 Yunping Dai,1 Meili Wang,1 Min Zheng,1 Bingxue Yan,1 Qinghong Zhu,1 and Ning Li1*

State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094,1 State Key Laboratory for Infectious Diseases Control and Prevention, China CDC, Beijing 100052,2 Animal Science and Technology College of He Bei Agricultural University, Baoding 071001, People'sRepublic of China3

Received 23 October 2005/ Accepted 6 January 2006

Transgenic mice expressing a recombinant human monoclonal antibody (rHMAb) against hantavirus were generated. These mice could be used as models to explore the possibilities of producing rHMAbs for therapeutic purposes. The highest concentration of the rHMAb in the milk of the transgenic females was 6.6 mg/ml. The rHMAb was also detected in the sera of pups fed by the transgenic females. Both the rHMAbs in the milk of transgenic mice and those in the sera of suckling pups were found to be active against hantaviruses, although the light chain of the antibody absorbed by the pups was modified by N-linked glycosylation.

* Corresponding author. Mailing address: State Key Lab For Agrobiotechnology, Yuanmingyuan Western Road 2#, Beijing 100094, People's Republic of China. Phone: 86 10 6273 3323. Fax: 86 10 6273 3904. E-mail: ninglbau{at}public3.bta.net.cn.

Journal of Virology, April 2006, p. 4183-4186, Vol. 80, No. 8
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.8.4183-4186.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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