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Journal of Virology, March 2006, p. 3083-3087, Vol. 80, No. 6
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.6.3083-3087.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Perforin Expression in the Gastrointestinal Mucosa Is Limited to Acute Simian Immunodeficiency Virus Infection

Máire F. Quigley,1 Kristina Abel,2,3,4 Bartek Zuber,6 Christopher J. Miller,2,3,4,5 Johan K. Sandberg,1 and Barbara L. Shacklett7*

Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden,1 Center for Comparative Medicine,2 California National Primate Research Center,3 Department of Internal Medicine, Division of Infectious Disease, School of Medicine,4 Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616,5 Mabtech AB, Box 1233, 13128 Nacka, Sweden,6 Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California 956167

Received 1 November 2005/ Accepted 18 December 2005

Perforin-mediated cytotoxicity is a major effector function of virus-specific CD8 T cells. We have investigated the expression of perforin in the gut, an important site of simian immunodeficiency virus (SIV) pathogenesis, during experimental SIV infection of rhesus macaques. We observed significant increases in perforin protein and mRNA expression levels in the colons of SIV-infected macaques as early as 21 days after infection. However, during chronic infection, despite ongoing viral replication, perforin expression returned to levels similar to those detected in SIV-naïve animals. These findings demonstrate the presence of a robust perforin-positive response in gastrointestinal CD8 T cells during acute, but not chronic, SIV infection.

* Corresponding author. Mailing address: Dept. of Medical Microbiology and Immunology, School of Medicine, University of California—Davis, 3327 Tupper Hall, One Shields Avenue, Davis, CA 95616. Phone: (530) 752-6785. Fax: (530) 752-8692. E-mail: blshacklett{at}ucdavis.edu.

Journal of Virology, March 2006, p. 3083-3087, Vol. 80, No. 6
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.6.3083-3087.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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