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Journal of Virology, March 2006, p. 3078-3082, Vol. 80, No. 6
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.6.3078-3082.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Reovirus Delays Diabetes Onset but Does Not Prevent Insulitis in Nonobese Diabetic Mice

J. Denise Wetzel,^1,2 Erik S. Barton,^2,3, James D. Chappell,^2,4 Geoffrey S. Baer,^2,3, Michelle Mochow-Grundy,^2,3, Steven E. Rodgers,^2,3,¶ Yu Shyr,⁵ Alvin C. Powers,^6,7 James W. Thomas,^3,6 and Terence S. Dermody^1,2,3*

Departments of Pediatrics,¹ Microbiology and Immunology,³ Pathology,⁴ Biostatistics,⁵ Medicine,⁶ Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232,² VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212⁷

Received 11 January 2005/ Accepted 19 December 2005

Mice infected with reovirus develop abnormalities in glucose homeostasis. Reovirus strain type 3 Abney (T3A) was capable of systemic infection of nonobese diabetic (NOD) mice, an experimental model of autoimmune diabetes. Reovirus antigen was detected in pancreatic islets of T3A-infected mice, and primary cultures of pancreatic islets from NOD mice supported T3A growth. Significantly fewer T3A-infected animals compared to uninfected controls developed diabetes. However, despite the alteration in diabetes penetrance, insulitis was evident in T3A-infected mice. These results suggest that viral infection of NOD mice alters autoimmune responses to ß-cell antigens and thereby delays development of diabetes.

Present address: Department of Pathology, Washington University School of Medicine, Campus Box 8118, 660 S. Euclid Avenue, St. Louis, MO 63110.

Present address: Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908.

Present address: Department of Medical Administration, Vanderbilt University School of Medicine, Nashville, TN 37232.

^¶ Present address: Department of Surgical Oncology, M. D. Anderson Cancer Center, Houston, TX 77030.

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