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Journal of Virology, March 2006, p. 2575-2577, Vol. 80, No. 5
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.5.2575-2577.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Human Herpesvirus 1 UL24 Gene Encodes a Potential PD-(D/E)XK Endonuclease

Lukasz Knizewski,1,{dagger} Lisa Kinch,2,{dagger} Nick V. Grishin,2,3 Leszek Rychlewski,4 and Krzysztof Ginalski1*

Interdisciplinary Centre for Mathematical and Computational Modelling, Warsaw University, 02-106 Warsaw, Poland,1 Howard Hughes Medical Institute, University of Texas, Southwestern Medical Center, Dallas, Texas 75390,2 Department of Biochemistry, University of Texas, Southwestern Medical Center, Dallas, Texas 75390,3 BioInfoBank Institute, 60-744 Poznan, Poland4

Received 6 September 2005/ Accepted 6 December 2005

Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded by the UL24 gene. The universal presence of UL24 in completed herpesviral genomes of three major subfamilies, Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, suggests a fundamental role for this predicted PD-(D/E)XK endonuclease activity in the viral life cycle.

* Corresponding author. Mailing address: Interdisciplinary Centre for Mathematical and Computational Modelling, Warsaw University, Pawinskiego 5A, 02-106 Warsaw, Poland. Phone: 48 22 8749100. Fax: 48 22 8749130. E-mail: kginal{at}icm.edu.pl.

{dagger} L.K. and L.K. contributed equally to this work.

Journal of Virology, March 2006, p. 2575-2577, Vol. 80, No. 5
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.5.2575-2577.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Bertrand, L., Pearson, A. (2008). The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin. J. Gen. Virol. 89: 1142-1151 [Abstract] [Full Text]  


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