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Journal of Virology, February 2006, p. 2069-2072, Vol. 80, No. 4
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.4.2069-2072.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

APOBEC3F and APOBEC3G mRNA Levels Do Not Correlate with Human Immunodeficiency Virus Type 1 Plasma Viremia or CD4+ T-Cell Count

Soo-Jin Cho,1 Henning Drechsler,2 Ryan C. Burke,2 Max Q. Arens,3 William Powderly,2 and Nicholas O. Davidson1*

Divisions of Gastroenterology,1 Infectious Diseases, Department of Medicine,2 Division of Laboratory Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 631103

Received 27 September 2005/ Accepted 17 November 2005

APOBEC3F and APOBEC3G (hA3F and hA3G) are part of an innate mechanism of antiretroviral defense. The human immunodeficiency virus type 1 (HIV-1) accessory protein Vif targets both proteins for proteasomal degradation. Using mRNA from peripheral blood mononuclear cells of 92 HIV-infected subjects not taking antiretroviral therapy and 19 HIV-uninfected controls, we found that hA3F (P < 0.001) and hA3G (P = 0.016) mRNA levels were lower in HIV-infected subjects and were positively correlated with one another (P = 0.003). However, we found no correlation in the abundance of either hA3F or hA3G mRNA with either viral load or CD4 counts in HIV-infected subjects.

* Corresponding author. Mailing address: Washington University School of Medicine, Division of Gastroenterology, Box 8124, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 362-2027. Fax: (314) 362-2033. E-mail: nod{at}wustl.edu.

Journal of Virology, February 2006, p. 2069-2072, Vol. 80, No. 4
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.4.2069-2072.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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