This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Soares, R.
Right arrow Articles by Sousa, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soares, R.
Right arrow Articles by Sousa, A. E.

 Previous Article  |  Next Article 

Journal of Virology, December 2006, p. 12425-12429, Vol. 80, No. 24
0022-538X/06/$08.00+0     doi:10.1128/JVI.01557-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Increased Frequency of Circulating CCR5+ CD4+ T Cells in Human Immunodeficiency Virus Type 2 Infection{triangledown}

Rui Soares,1 Russell Foxall,1 Adriana Albuquerque,1 Catarina Cortesão,1 Miguel Garcia,1,2 Rui M. M. Victorino,1,3 and Ana E. Sousa1*

Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal,1 Instituto Superior de Ciências da Saúde Egas Moniz, Quinta da Granja, 2829-511 Monte da Caparica, Portugal; and,2 Medicina 2, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-035 Lisbon, Portugal3

Received 20 July 2006/ Accepted 28 September 2006

CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.

* Corresponding author. Mailing address: Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal. Phone: 351 21 799 95 25. Fax: 351 21 799 95 27. E-mail: asousa{at}fm.ul.pt.

{triangledown} Published ahead of print on 11 October 2006.

Journal of Virology, December 2006, p. 12425-12429, Vol. 80, No. 24
0022-538X/06/$08.00+0     doi:10.1128/JVI.01557-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Foxall, R. B., Cortesao, C. S., Albuquerque, A. S., Soares, R. S., Victorino, R. M. M., Sousa, A. E. (2008). Gag-Specific CD4+ T-Cell Frequency Is Inversely Correlated with Proviral Load and Directly Correlated with Immune Activation in Infection with Human Immunodeficiency Virus Type 2 (HIV-2) but Not HIV-1. J. Virol. 82: 9795-9799 [Abstract] [Full Text]  
  • Gautier, D., Beq, S., Cortesao, C. S., Sousa, A. E., Cheynier, R. (2007). Efficient Thymopoiesis Contributes to the Maintenance of Peripheral CD4 T Cells during Chronic Human Immunodeficiency Virus Type 2 Infection. J. Virol. 81: 12685-12688 [Abstract] [Full Text]  
  • Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A. W., Piatak, M. Jr., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M. K., Grossman, Z., Picker, L. J. (2007). Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection. JEM 204: 2171-2185 [Abstract] [Full Text]  
  • Albuquerque, A. S., Cortesao, C. S., Foxall, R. B., Soares, R. S., Victorino, R. M. M., Sousa, A. E. (2007). Rate of Increase in Circulating IL-7 and Loss of IL-7R{alpha} Expression Differ in HIV-1 and HIV-2 Infections: Two Lymphopenic Diseases with Similar Hyperimmune Activation but Distinct Outcomes. J. Immunol. 178: 3252-3259 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»