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Journal of Virology, December 2006, p. 12425-12429, Vol. 80, No. 24
0022-538X/06/$08.00+0     doi:10.1128/JVI.01557-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Increased Frequency of Circulating CCR5+ CD4+ T Cells in Human Immunodeficiency Virus Type 2 Infection{triangledown}

Rui Soares,1 Russell Foxall,1 Adriana Albuquerque,1 Catarina Cortesão,1 Miguel Garcia,1,2 Rui M. M. Victorino,1,3 and Ana E. Sousa1*

Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal,1 Instituto Superior de Ciências da Saúde Egas Moniz, Quinta da Granja, 2829-511 Monte da Caparica, Portugal; and,2 Medicina 2, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-035 Lisbon, Portugal3

Received 20 July 2006/ Accepted 28 September 2006

CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.

* Corresponding author. Mailing address: Unidade de Imunologia Clínica, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal. Phone: 351 21 799 95 25. Fax: 351 21 799 95 27. E-mail: asousa{at}fm.ul.pt.

{triangledown} Published ahead of print on 11 October 2006.

Journal of Virology, December 2006, p. 12425-12429, Vol. 80, No. 24
0022-538X/06/$08.00+0     doi:10.1128/JVI.01557-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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