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Journal of Virology, December 2006, p. 12025-12031, Vol. 80, No. 24
0022-538X/06/$08.00+0     doi:10.1128/JVI.00693-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Theiler's Murine Encephalomyelitis Virus Leader Protein Amino Acid Residue 57 Regulates Subgroup-Specific Virus Growth on BHK-21 Cells{triangledown}

Masumi Takano-Maruyama, Yoshiro Ohara,* Kunihiko Asakura, and Takako Okuwa

Department of Microbiology, Kanazawa Medical University, Ishikawa 920-0293, Japan

Received 5 April 2006/ Accepted 15 September 2006

Strains of Theiler's murine encephalomyelitis virus (TMEV) are divided into two subgroups, TO and GDVII. TMEV strains show subgroup-specific virus growth and cell tropism and induce subgroup-specific diseases. Using site-directed mutagenesis, we demonstrated that the amino acid at position 57 of the leader protein (L57), which is located at the most N-terminal part of the polyprotein, regulates subgroup-specific virus growth on BHK-21 cells. Further study suggested that L57 may regulate viral RNA encapsidation, although it does not affect the synthesis of viral proteins or the assembly of viral intermediates.

* Corresponding author. Mailing address: Department of Microbiology, Kanazawa Medical University, 1-1 Uchinada, Ishikawa 920-0293, Japan. Phone: 81-76-286-2211. Fax: 81-76-286-3961. E-mail: ohara{at}kanazawa-med.ac.jp.

{triangledown} Published ahead of print on 27 September 2006.

Journal of Virology, December 2006, p. 12025-12031, Vol. 80, No. 24
0022-538X/06/$08.00+0     doi:10.1128/JVI.00693-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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