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 Previous Article

Journal of Virology, December 2006, p. 11892-11896, Vol. 80, No. 23
0022-538X/06/$08.00+0     doi:10.1128/JVI.00932-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Entire Genome of a Strain of Human Immunodeficiency Virus Type 1 with a Deletion of nef That Was Recovered 20 Years after Primary Infection: Large Pool of Proviruses with Deletions of env{triangledown}

Graziella Calugi,1 Francesco Montella,2 Cartesio Favalli,1 and Arrigo Benedetto1*

University of Rome, Tor Vergata, Clinical Microbiology and Virology,1 Ente Ospedaliero San Giovanni, Rome, Italy2

Received 8 May 2006/ Accepted 12 September 2006

We report the complete sequence analysis of the provirus harbored in a long-term nonprogressor (patient SG1) 20 years after the first infection with a human immunodeficiency virus type 1 strain lacking nef. The sequencing showed large deletions in the nef-nef and nef-U3 regions. Except for vpu, all of the other accessory genes were intact. The gag and pol genes did not show significant alterations. We found large deletions in env, spanning the V1, V2, V3, V4, and V5 regions. We believe that, when down-regulation of the class 1 major histocompatibility complex molecules is inhibited by the lack of nef function, the cells containing Env-defective molecules evade cytotoxic T lymphocyte killing and accumulate progressively.

* Corresponding author. Mailing address: University of Rome, Tor Vergata, Clinical Microbiology and Virology, Rome, Italy. Phone: 39-335-6227197. Fax: 39-06-20902078. E-mail: arbenvir{at}virgilio.it.

{triangledown} Published ahead of print on 20 September 2006.

Journal of Virology, December 2006, p. 11892-11896, Vol. 80, No. 23
0022-538X/06/$08.00+0     doi:10.1128/JVI.00932-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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