This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shore, A. M.
Right arrow Articles by Brennan, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shore, A. M.
Right arrow Articles by Brennan, P.

 Previous Article  |  Next Article 

Journal of Virology, November 2006, p. 11191-11199, Vol. 80, No. 22
0022-538X/06/$08.00+0     doi:10.1128/JVI.00983-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Epstein-Barr Virus Represses the FoxO1 Transcription Factor through Latent Membrane Protein 1 and Latent Membrane Protein 2A{triangledown}

Angharad M. Shore,1 Paul C. White,1 Rosaline C.-Y. Hui,2 Abdelkader Essafi,2 Eric W.-F. Lam,2 Martin Rowe,3 and Paul Brennan1*

Medical Biochemistry and Immunology, Henry Wellcome Research Building, Cardiff University, Heath Park, Cardiff CF14 4XX, United Kingdom,1 Cancer Research UK Labs and Department of Oncology, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom,2 CRUK Institute for Cancer Studies, University of Birmingham, Edgbaston B15 2TJ, United Kingdom3

Received 12 May 2006/ Accepted 23 August 2006

Epstein-Barr virus (EBV) infection is associated with the development of many B-cell lymphomas, including Burkitt's lymphoma, Hodgkin's lymphoma, and posttransplant lymphoproliferative disease. The virus alters a diverse range of cellular molecules, which leads to B-cell growth and immortalization. This study was initiated to investigate the interplay between EBV and a proapoptotic transcription factor target, FoxO1. In this report, we show that EBV infection of B cells leads to the downregulation of FoxO1 expression by phosphatidylinositol 3-kinase-mediated nuclear export, by inhibition of FoxO1 mRNA expression, and by alteration of posttranslational modifications. This repression directly correlates with the expression of the FoxO1 target gene Bcl-6 and inversely correlates with the FoxO1-regulated gene Cyclin D2. Expression of the EBV genes for latent membrane protein 1 and latent membrane protein 2A decreases FoxO1 expression. Thus, our data elucidate distinct mechanisms for the regulation of the proapoptotic transcription factor FoxO1 by EBV.

* Corresponding author. Mailing address: Medical Biochemistry and Immunology, Henry Wellcome Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom. Phone: 44 29 20744517. Fax: 44 29 2074 4905. E-mail: brennanp{at}cardiff.ac.uk.

{triangledown} Published ahead of print on 30 August 2006.

Journal of Virology, November 2006, p. 11191-11199, Vol. 80, No. 22
0022-538X/06/$08.00+0     doi:10.1128/JVI.00983-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Meyer, R. D., Laz, E. V., Su, T., Waxman, D. J. (2009). Male-Specific Hepatic Bcl6: Growth Hormone-Induced Block of Transcription Elongation in Females and Binding to Target Genes Inversely Coordinated with STAT5. Mol. Endocrinol. 23: 1914-1926 [Abstract] [Full Text]  
  • McLoughlin, T. J., Smith, S. M., DeLong, A. D., Wang, H., Unterman, T. G., Esser, K. A. (2009). FoxO1 induces apoptosis in skeletal myotubes in a DNA-binding-dependent manner. Am. J. Physiol. Cell Physiol. 297: C548-C555 [Abstract] [Full Text]  
  • Chen, Y.-R., Liu, M.-T., Chang, Y.-T., Wu, C.-C., Hu, C.-Y., Chen, J.-Y. (2008). Epstein-Barr Virus Latent Membrane Protein 1 Represses DNA Repair through the PI3K/Akt/FOXO3a Pathway in Human Epithelial Cells. J. Virol. 82: 8124-8137 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»