This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aasa-Chapman, M. M. I.
Right arrow Articles by McKnight, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aasa-Chapman, M. M. I.
Right arrow Articles by McKnight, A.

 Previous Article  |  Next Article 

Journal of Virology, November 2006, p. 10884-10889, Vol. 80, No. 21
0022-538X/06/$08.00+0     doi:10.1128/JVI.01030-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Novel Envelope Determinants for CCR3 Use by Human Immunodeficiency Virus

Marlén M. I. Aasa-Chapman,1 Craig R. Seymour,1 Ian Williams,2 and Áine McKnight1*

Wohl Virion Centre, Division of Infection and Immunity,1 Centre for Sexual Health and HIV Research, University College London, London, United Kingdom2

Received 19 May 2006/ Accepted 3 August 2006

Human immunodeficiency virus type 1 can generally use CCR3 and CCR5 for cell entry. We show that envelopes with novel phenotypes arise during "coreceptor switch": one loses the ability to use CCR3 (R5-only phenotype), and another gains use of CXCR4 in addition to CCR5 and CCR3 (R3/R5/X4-using phenotype). The envelope determinants for CCR3 use mapped to three amino acids. One, N356 in conserved region 3, is a potential glycosylation site and has not previously been associated with coreceptor use. The other two, R440 and N448 in conserved region 4, are proximal to but distinct from residues already identified as being important for CCR5 binding.

* Corresponding author. Mailing address: Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and The London, Queen Mary's School of Medicine and Dentistry, The Blizard Building, 4 Newark Street, Whitechapel, London E1 2AT, United Kingdom. Phone: 44 20 7679 9605. Fax: 44 20 7967 9555. E-mail: a.mcknight{at}qmul.ac.uk.

Journal of Virology, November 2006, p. 10884-10889, Vol. 80, No. 21
0022-538X/06/$08.00+0     doi:10.1128/JVI.01030-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Nedellec, R., Coetzer, M., Shimizu, N., Hoshino, H., Polonis, V. R., Morris, L., Martensson, U. E. A., Binley, J., Overbaugh, J., Mosier, D. E. (2009). Virus Entry via the Alternative Coreceptors CCR3 and FPRL1 Differs by Human Immunodeficiency Virus Type 1 Subtype. J. Virol. 83: 8353-8363 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»