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Journal of Virology, November 2006, p. 10862-10867, Vol. 80, No. 21
0022-538X/06/$08.00+0     doi:10.1128/JVI.01589-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Role of the Low-Density Lipoprotein Receptor in Entry of Bovine Viral Diarrhea Virus{triangledown}

Thomas Krey,1 Etienne Moussay,2 Heinz-Jürgen Thiel,1 and Till Rümenapf1*

Institut für Virologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität, Frankfurter Str. 107, 35392 Giessen, Germany,1 Institut für Hygiene und Infektionskrankheiten der Tiere, Fachbereich Veterinärmedizin, Justus-Liebig-Universität, Frankfurter Str. 85-89, 35392 Giessen, Germany2

Received 25 July 2006/ Accepted 15 August 2006

Among several proposed cellular receptors for bovine viral diarrhea virus (BVDV), the low-density lipoprotein (LDL) receptor is of special interest because it is also considered a receptor for the related hepatitis C virus. It has been reported that an anti-LDL receptor monoclonal antibody blocked the infection of bovine cells by BVDV and that the resistance of bovine CRIB cells (cells resistant to infection with BVDV) (E. F. Flores and R. O. Donis, Virology 208:565-575, 1995) to BVDV infection was due to a lack of the LDL receptor (V. Agnello et al., Proc. Natl. Acad. Sci. USA 96:12766-12771, 1999). In connection with our studies on BVDV entry, we reevaluated the putative role of the LDL receptor as a cellular receptor for BVDV. It was first clearly demonstrated that neither of two monoclonal antibodies against the LDL receptor inhibited BVDV infection of two bovine cell lines. Furthermore, the LDL receptor was detected on the surface of CRIB cells. The functionality of the LDL receptor on CRIB cells was demonstrated by the internalization of fluorescently labeled LDL. In conclusion, at present no experimental evidence supports an involvement of the LDL receptor in BVDV invasion.

* Corresponding author. Mailing address: Institut für Virologie, Frankfurter Str. 107, D-35392 Giessen, Germany. Phone: 49-641-99-38356. Fax: 49-641-99-38359. E-mail: Till.H.Ruemenapf{at}vetmed.uni-giessen.de.

{triangledown} Published ahead of print on 23 August 2006.

Journal of Virology, November 2006, p. 10862-10867, Vol. 80, No. 21
0022-538X/06/$08.00+0     doi:10.1128/JVI.01589-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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