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Journal of Virology, October 2006, p. 10248-10252, Vol. 80, No. 20
0022-538X/06/$08.00+0     doi:10.1128/JVI.01384-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Differential Signaling Networks Induced by Mild and Lethal Hemorrhagic Fever Virus Infections{dagger}

Gavin C. Bowick,1,2 Susan M. Fennewald,1,2 Barry L. Elsom,1,2 Judith F. Aronson,1,2 Bruce A. Luxon,2,3,4 David G. Gorenstein,2,3 and Norbert K. Herzog1,2*

Department of Pathology,1 Center for Biodefense and Emerging Infectious Diseases,2 Department of Biochemistry and Molecular Biology,3 Bioinformatics Program, University of Texas Medical Branch, Galveston, Texas 775554

Received 30 June 2006/ Accepted 2 August 2006

The family Arenaviridae includes several National Institutes of Allergy and Infections Diseases category A select agents which cause hemorrhagic fever. There are few vaccines available, and treatment is limited to ribavirin, which varies in efficacy. Development of new antiviral compounds has been hindered by a lack of understanding of the molecular basis of pathogenesis. We used two variants of Pichinde virus, one attenuated and one virulent in the guinea pig model, to delineate the host determinants which lead to either viral clearance or lethal disease. By analyzing protein level changes using pathway analysis, we have identified key intermediates which may be targets for therapeutic intervention.

* Corresponding author. Mailing address: University of Texas Medical Branch, 201 University Blvd., Galveston, TX 77555. Phone: (409) 772-3938. Fax: (409) 747-2400. E-mail: nherzog{at}utmb.edu.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org/.

Journal of Virology, October 2006, p. 10248-10252, Vol. 80, No. 20
0022-538X/06/$08.00+0     doi:10.1128/JVI.01384-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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