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Journal of Virology, January 2006, p. 562-570, Vol. 80, No. 2
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.2.562-570.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Evolution of Broad Host Range in Retroviruses Leads to Cell Death Mediated by Highly Cytopathic Variants

G. Jonah A. Rainey{dagger} and John M. Coffin*

Department of Biochemistry and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts

Received 14 April 2005/ Accepted 17 October 2005

The ability of many retroviruses to cause disease can be correlated to their cytopathic effect (CPE) in tissue culture characterized by an acute period of cell death and viral DNA accumulation. Here, we show that mutants of a subgroup B avian retrovirus (Alpharetrovirus) cause a very dramatic CPE in certain susceptible avian cells that is coincident with elevated levels of apoptosis, as measured by nuclear morphology, and persistent viral DNA accumulation. These mutants also have a broadly extended host range that includes rodent, cat, dog, monkey, and human cells (31). Previously, we have shown that the mutants exhibit diminished resistance to superinfection. The results presented here have important implications for the process of evolution of retroviruses to use distinct cellular receptors.

* Corresponding author. Mailing address: 136 Harrison Ave., Boston, MA 02111. Phone: (617) 636-6528. Fax: (617) 636-4086. E-mail: john.coffin{at}tufts.edu.

{dagger} Present address: The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd., La Jolla, CA 92037.

Journal of Virology, January 2006, p. 562-570, Vol. 80, No. 2
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.2.562-570.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Zhao, X., Yoshimura, F. K. (2008). Expression of Murine Leukemia Virus Envelope Protein Is Sufficient for the Induction of Apoptosis. J. Virol. 82: 2586-2589 [Abstract] [Full Text]  


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