This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O'Neill, E.
Right arrow Articles by Garcia, J. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Neill, E.
Right arrow Articles by Garcia, J. V.

 Previous Article  |  Next Article 

Journal of Virology, September 2006, p. 8824-8829, Vol. 80, No. 17
0022-538X/06/$08.00+0     doi:10.1128/JVI.00910-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Intra- and Intersubtype Alternative Pak2-Activating Structural Motifs of Human Immunodeficiency Virus Type 1 Nef

Eduardo O'Neill,1* Laura L. Baugh,1 Vladimir A. Novitsky,2 Myron E. Essex,2 and J. Victor Garcia1

Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390,1 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 021152

Received 3 May 2006/ Accepted 14 June 2006

The design of antiviral strategies against human immunodeficiency virus type 1 (HIV-1) has been largely derived from studies of subtype B viruses, although they constitute only 12% of infections worldwide. At 50% of all HIV-1 infections worldwide, subtype C viruses are the most predominant. Here, we present evidence that subtype C Nefs display functional Pak2-activating motifs that differ from those found in subtype B and E Nefs. The identification of multiple Pak2-activating structural motifs that singly affect one Nef activity revealed a functional plasticity that has implications for future drug and vaccine design aimed at HIV-1 Nef and its effects on the deregulation of the immune system.

* Corresponding author. Mailing address: Department of Internal Medicine, Division of Infectious Diseases Y9.214, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75390-9113. Phone: (214) 648-9264. Fax: (214) 648-0231. E-mail: eduardo.oneill{at}utsouthwestern.edu.

Journal of Virology, September 2006, p. 8824-8829, Vol. 80, No. 17
0022-538X/06/$08.00+0     doi:10.1128/JVI.00910-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»