This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Klingström, J.
Right arrow Articles by Ahlm, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klingström, J.
Right arrow Articles by Ahlm, C.

 Previous Article  |  Next Article 

Journal of Virology, August 2006, p. 8279-8282, Vol. 80, No. 16
0022-538X/06/$08.00+0     doi:10.1128/JVI.00742-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Loss of Cell Membrane Integrity in Puumala Hantavirus-Infected Patients Correlates with Levels of Epithelial Cell Apoptosis and Perforin

Jonas Klingström,1,2* Jonas Hardestam,1,2 Malin Stoltz,1 Bartek Zuber,3 Åke Lundkvist,1,2 Stig Linder,4 and Clas Ahlm5

Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden,1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden,2 Mabtech AB, Box 1233, S-131 52 Nacka Strand, Sweden,3 Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden,4 Division of Infectious Diseases, Department of Clinical Microbiology, Umeå University, S-901 85 Umeå, Sweden5

Received 12 April 2006/ Accepted 16 May 2006

Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome are two diseases caused by hantaviruses. Capillary leakage is a hallmark of hantavirus infection. Pathogenic hantaviruses are not cytotoxic, but elevated levels of serum lactate dehydrogenase (LDH), indicative of cellular damage, are observed in patients. We report increased levels of serum perforin, granzyme B, and the epithelial cell apoptosis marker caspase-cleaved cytokeratin-18 during Puumala hantavirus infection. Significant correlation was observed between the levels of LDH and perforin and the levels of LDH and caspase-cleaved cytokeratin-18, suggesting that tissue damage is due to an immune reaction and that epithelial apoptosis contributed significantly to the damage.

* Corresponding author. Mailing address: Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden. Phone: 46 8 457 25 07. Fax: 46 8 30 79 57. E-mail: jonas.klingstrom{at}smi.ki.se.

Journal of Virology, August 2006, p. 8279-8282, Vol. 80, No. 16
0022-538X/06/$08.00+0     doi:10.1128/JVI.00742-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Xu, F., Liang, X., Tesh, R. B., Xiao, S.-Y. (2008). Characterization of cell-death pathways in Punta Toro virus-induced hepatocyte injury. J. Gen. Virol. 89: 2175-2181 [Abstract] [Full Text]  
  • Stoltz, M., Ahlm, C., Lundkvist, A., Klingstrom, J. (2007). Lambda Interferon (IFN-{lambda}) in Serum Is Decreased in Hantavirus-Infected Patients, and In Vitro-Established Infection Is Insensitive to Treatment with All IFNs and Inhibits IFN-{gamma}-Induced Nitric Oxide Production. J. Virol. 81: 8685-8691 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»