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Journal of Virology, August 2006, p. 8271-8273, Vol. 80, No. 16
0022-538X/06/$08.00+0     doi:10.1128/JVI.00656-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Human CD4⁺ CD25^high Cells Suppress Proliferative Memory Lymphocyte Responses to Herpes Simplex Virus Type 2

Department of Medicine, University of Washington, Seattle, Washington 98195,¹ Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195,² Department of Pathobiology, University of Washington, Seattle, Washington 98195,³ Fred Hutchinson Cancer Research Center, Seattle, Washington 98109,⁴ Benaroya Research Institute, Seattle, Washington 98101⁵

Received 31 March 2006/ Accepted 21 May 2006

Lymphocytes with the regulatory CD4⁺ CD25⁺ phenotype frequently suppress memory T-cell responses. Murine herpes simplex virus type 1 (HSV-1) models have shown that CD4⁺ CD25⁺ cells can limit immunity-mediated corneal damage but slow viral clearance. We investigated the effect of CD4⁺ CD25⁺ cells from healthy HSV-2-infected humans on recall proliferative (CD4) responses to HSV-2. Depletion and reconstitution experiments were consistent with a suppressive effect of autologous blood-derived CD4⁺ CD25⁺ cells for whole HSV-2 antigen. Regulatory T cells may modulate human CD4 memory responses to HSV-2 and influence their antiviral and inflammatory functions.

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