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Journal of Virology, August 2006, p. 8271-8273, Vol. 80, No. 16
0022-538X/06/$08.00+0     doi:10.1128/JVI.00656-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Human CD4+ CD25high Cells Suppress Proliferative Memory Lymphocyte Responses to Herpes Simplex Virus Type 2

George A. Diaz1 and David M. Koelle1,2,3,4,5*

Department of Medicine, University of Washington, Seattle, Washington 98195,1 Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195,2 Department of Pathobiology, University of Washington, Seattle, Washington 98195,3 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109,4 Benaroya Research Institute, Seattle, Washington 981015

Received 31 March 2006/ Accepted 21 May 2006

Lymphocytes with the regulatory CD4+ CD25+ phenotype frequently suppress memory T-cell responses. Murine herpes simplex virus type 1 (HSV-1) models have shown that CD4+ CD25+ cells can limit immunity-mediated corneal damage but slow viral clearance. We investigated the effect of CD4+ CD25+ cells from healthy HSV-2-infected humans on recall proliferative (CD4) responses to HSV-2. Depletion and reconstitution experiments were consistent with a suppressive effect of autologous blood-derived CD4+ CD25+ cells for whole HSV-2 antigen. Regulatory T cells may modulate human CD4 memory responses to HSV-2 and influence their antiviral and inflammatory functions.

* Corresponding author. Mailing address: Harborview Medical Center, Mail Stop 359690, 325 Ninth Avenue, Seattle, WA 98104. Phone: (206) 341-5207. Fax: (206) 341-5203. E-mail: viralimm{at}u.washington.edu.

Journal of Virology, August 2006, p. 8271-8273, Vol. 80, No. 16
0022-538X/06/$08.00+0     doi:10.1128/JVI.00656-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Nesburn, A. B., Bettahi, I., Dasgupta, G., Chentoufi, A. A., Zhang, X., You, S., Morishige, N., Wahlert, A. J., Brown, D. J., Jester, J. V., Wechsler, S. L., BenMohamed, L. (2007). Functional Foxp3+ CD4+ CD25(Bright+) "Natural" Regulatory T Cells Are Abundant in Rabbit Conjunctiva and Suppress Virus-Specific CD4+ and CD8+ Effector T Cells during Ocular Herpes Infection. J. Virol. 81: 7647-7661 [Abstract] [Full Text]  


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