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Journal of Virology, August 2006, p. 8259-8262, Vol. 80, No. 16
0022-538X/06/$08.00+0     doi:10.1128/JVI.00776-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The L2 Minor Capsid Protein of Low-Risk Human Papillomavirus Type 11 Interacts with Host Nuclear Import Receptors and Viral DNA

J. Bordeaux, S. Forte, E. Harding, M. S. Darshan, K. Klucevsek, and J. Moroianu*

Biology Department, Boston College, Chestnut Hill, Massachusetts 02467

Received 17 April 2006/ Accepted 30 May 2006

Analysis of the interactions of low-risk human papillomavirus type 11 (HPV11) L2 with karyopherin ß (Kap ß) nuclear import receptors revealed that L2 interacted with Kap ß1, Kap ß2, and Kap ß3 and formed a complex with the Kap {alpha}2ß1 heterodimer. HPV11 L2 contains two nuclear localization signals (NLSs)—in the N terminus and the C terminus—that could mediate its nuclear import via a classical pathway. Each NLS was functional in vivo, and deletion of both of them abolished L2 nuclear localization. Both NLSs interacted with the viral DNA. Thus, HPV11 L2 can interact with several karyopherins and the viral DNA and may enter the nucleus via multiple pathways.

* Corresponding author. Mailing address: Boston College, Biology Department, Higgins Hall, Room 578, 140 Commonwealth Avenue, Chestnut Hill, MA 02467. Phone: (617) 552-1713. Fax: (617) 552-2011. E-mail: moroianu{at}bc.edu.

Journal of Virology, August 2006, p. 8259-8262, Vol. 80, No. 16
0022-538X/06/$08.00+0     doi:10.1128/JVI.00776-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Conway, M.J., Meyers, C. (2009). Replication and Assembly of Human Papillomaviruses. JDR 88: 307-317 [Abstract] [Full Text]  
  • Laniosz, V., Nguyen, K. C., Meneses, P. I. (2007). Bovine Papillomavirus Type 1 Infection Is Mediated by SNARE Syntaxin 18. J. Virol. 81: 7435-7448 [Abstract] [Full Text]  


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