This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chang, Y.
Right arrow Articles by Tsai, C.-H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chang, Y.
Right arrow Articles by Tsai, C.-H.

 Previous Article  |  Next Article 

Journal of Virology, August 2006, p. 7748-7755, Vol. 80, No. 15
0022-538X/06/$08.00+0     doi:10.1128/JVI.02608-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Induction of the Early Growth Response 1 Gene by Epstein-Barr Virus Lytic Transactivator Zta

Yao Chang,1,2 Heng-Huan Lee,1 Yu-Te Chen,1 Jean Lu,1 Shih-Yi Wu,2 Chaio-Wei Chen,2 Kenzo Takada,3 and Ching-Hwa Tsai1*

Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan,1 Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan,2 Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan3

Received 15 December 2005/ Accepted 16 May 2006

Early growth response 1 (Egr-1) is a cellular transcription factor involved in diverse biologic functions. Egr-1 has been associated with Epstein-Barr virus (EBV) infection, but it is still unknown whether any EBV protein regulates Egr-1 expression. In this study, we first showed that EBV reactivation is involved in upregulation of Egr-1 and that Egr-1 can be induced by Zta, an EBV lytic transactivator. Zta not only binds to the Egr-1 promoter but also activates the ERK signaling pathway to trigger binding of Elk-1 to the Egr-1 promoter. In addition, knockdown of Egr-1 significantly reduces the spontaneous expression of Zta and Rta in EBV-infected 293 cells, suggesting that a positive-feedback network involving Egr-1 is required for EBV reactivation. This study also implies that Zta has the potential to affect expression of certain genes through Egr-1.

* Corresponding author. Mailing address: Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Room 714, Number 1, Section 1, Jen-Ai Road, Taipei, Taiwan. Phone: 886-2-2312-3456, ext. 8298. Fax: 886-2-2391-5180. E-mail: chtsai{at}ha.mc.ntu.edu.tw.

Journal of Virology, August 2006, p. 7748-7755, Vol. 80, No. 15
0022-538X/06/$08.00+0     doi:10.1128/JVI.02608-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tsai, S.-C., Lin, S.-J., Chen, P.-W., Luo, W.-Y., Yeh, T.-H., Wang, H.-W., Chen, C.-J., Tsai, C.-H. (2009). EBV Zta protein induces the expression of interleukin-13, promoting the proliferation of EBV-infected B cells and lymphoblastoid cell lines. Blood 114: 109-118 [Abstract] [Full Text]  
  • Heather, J., Flower, K., Isaac, S., Sinclair, A. J. (2009). The Epstein-Barr virus lytic cycle activator Zta interacts with methylated ZRE in the promoter of host target gene egr1. J. Gen. Virol. 90: 1450-1454 [Abstract] [Full Text]  
  • Hsiao, J.-R., Chang, K.-C., Chen, C.-W., Wu, S.-Y., Su, I.-J., Hsu, M.-C., Jin, Y.-T., Tsai, S.-T., Takada, K., Chang, Y. (2009). Endoplasmic Reticulum Stress Triggers XBP-1-Mediated Up-regulation of an EBV Oncoprotein in Nasopharyngeal Carcinoma. Cancer Res. 69: 4461-4467 [Abstract] [Full Text]  
  • Li, D., Qian, L., Chen, C., Shi, M., Yu, M., Hu, M., Song, L., Shen, B., Guo, N. (2009). Down-Regulation of MHC Class II Expression through Inhibition of CIITA Transcription by Lytic Transactivator Zta during Epstein-Barr Virus Reactivation. J. Immunol. 182: 1799-1809 [Abstract] [Full Text]  
  • Lee, Y.-H., Chiu, Y.-F., Wang, W.-H., Chang, L.-K., Liu, S.-T. (2008). Activation of the ERK signal transduction pathway by Epstein-Barr virus immediate-early protein Rta. J. Gen. Virol. 89: 2437-2446 [Abstract] [Full Text]  
  • Lee, H.-H., Chang, S.-S., Lin, S.-J., Chua, H.-H., Tsai, T.-J., Tsai, K., Lo, Y.-C., Chen, H.-C., Tsai, C.-H. (2008). Essential role of PKC{delta} in histone deacetylase inhibitor-induced Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells. J. Gen. Virol. 89: 878-883 [Abstract] [Full Text]  
  • Hsu, M., Wu, S.-Y., Chang, S.-S., Su, I.-J., Tsai, C.-H., Lai, S.-J., Shiau, A.-L., Takada, K., Chang, Y. (2008). Epstein-Barr Virus Lytic Transactivator Zta Enhances Chemotactic Activity through Induction of Interleukin-8 in Nasopharyngeal Carcinoma Cells. J. Virol. 82: 3679-3688 [Abstract] [Full Text]  
  • Chua, H.-H., Lee, H.-H., Chang, S.-S., Lu, C.-C., Yeh, T.-H., Hsu, T.-Y., Cheng, T.-H., Cheng, J.-T., Chen, M.-R., Tsai, C.-H. (2007). Role of the TSG101 Gene in Epstein-Barr Virus Late Gene Transcription. J. Virol. 81: 2459-2471 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»