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 Previous Article

Journal of Virology, July 2006, p. 7281-7283, Vol. 80, No. 14
0022-538X/06/$08.00+0     doi:10.1128/JVI.00497-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Epstein-Barr Virus Shed in Saliva Is High in B-Cell-Tropic Glycoprotein gp42

R. Jiang, R. S. Scott, and L. M. Hutt-Fletcher*

Department of Microbiology and Immunology, Center for Molecular and Tumor Virology and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana

Received 9 March 2006/ Accepted 1 May 2006

Epstein-Barr virus is an orally transmitted human herpesvirus that infects epithelial cells and establishes latency in memory B lymphocytes. Movement of virus between the two cell types is facilitated by changes in amounts of an envelope glycoprotein, gp42, which are effected by interaction of gp42 with HLA class II in a B cell. Here we used the differential ability of virus to bind to CD21-positive B cells and CD21-negative epithelial cells, which is also influenced by levels of gp42, to determine that the majority of virus shed in saliva is derived from an HLA class II-negative cell.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71130. Phone: (318) 675-4948. Fax: (318) 675-5764. E-mail: lhuttf{at}lsuhsc.edu.

Journal of Virology, July 2006, p. 7281-7283, Vol. 80, No. 14
0022-538X/06/$08.00+0     doi:10.1128/JVI.00497-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wu, L., Hutt-Fletcher, L. M. (2007). Compatibility of the gH homologues of Epstein-Barr virus and related lymphocryptoviruses. J. Gen. Virol. 88: 2129-2136 [Abstract] [Full Text]  
  • Hutt-Fletcher, L. M. (2007). Epstein-Barr Virus Entry. J. Virol. 81: 7825-7832 [Full Text]  
  • Walling, D. M., Ray, A. J., Nichols, J. E., Flaitz, C. M., Nichols, C. M. (2007). Epstein-Barr Virus Infection of Langerhans Cell Precursors as a Mechanism of Oral Epithelial Entry, Persistence, and Reactivation. J. Virol. 81: 7249-7268 [Abstract] [Full Text]  
  • Turk, S. M., Jiang, R., Chesnokova, L. S., Hutt-Fletcher, L. M. (2006). Antibodies to gp350/220 Enhance the Ability of Epstein-Barr Virus To Infect Epithelial Cells. J. Virol. 80: 9628-9633 [Abstract] [Full Text]  


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