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Journal of Virology, July 2006, p. 6702-6705, Vol. 80, No. 13
0022-538X/06/$08.00+0     doi:10.1128/JVI.00329-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Active Viremia in Rotavirus-Infected Mice

Sarah E. Blutt,1,3 Martijn Fenaux ,2,{dagger} Kelly L. Warfield,1,{ddagger} Harry B. Greenberg,2 and Margaret E. Conner1,3*

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030,1 Department of Gastroenterology, Stanford University Medical School, Palo Alto, California 94304,2 Michael E. Debakey Veterans Affairs Medical Center, Houston, Texas 770303

Received 15 February 2006/ Accepted 20 April 2006

Rotavirus circulates extraintestinally in animals used as models for rotavirus infection and in children. Rotavirus infection in mice was used to define host or viral factors that affect rotavirus viremia. Antigenemia was observed with homologous and heterologous rotaviruses, and neither age nor mouse strain genetics altered the occurrence of rotavirus antigenemia or viremia. Rotavirus RNA and infectious virus were present in sera and associated with the plasma fraction of blood in all infected mice. These findings indicate that antigenemia/viremia occurs routinely in rotavirus infections and imply that infectious rotavirus has access to any extraintestinal cell within contact of blood.

* Corresponding author. Mailing address: Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Phone: (713) 798-4481. Fax: (713) 798-3586. E-mail: mconner{at}bcm.tmc.edu.

{dagger} Present address: Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404.

{ddagger} Present address: United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702.

Journal of Virology, July 2006, p. 6702-6705, Vol. 80, No. 13
0022-538X/06/$08.00+0     doi:10.1128/JVI.00329-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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