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Journal of Virology, June 2006, p. 6177-6181, Vol. 80, No. 12
0022-538X/06/$08.00+0     doi:10.1128/JVI.02625-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells

Vincent Holl,1 Maryse Peressin,1 Thomas Decoville,1 Sylvie Schmidt,1 Susan Zolla-Pazner,2 Anne-Marie Aubertin,1 and Christiane Moog1*

EA 3770, ULP, Institut de Virologie, 3 rue Koeberlé, 67000 Strasbourg, France,1 Veterans Affairs and NYU Medical Centers, 423 East 23rd Street, Room 18124N, New York, New York 100102

Received 16 December 2005/ Accepted 22 March 2006

Only five monoclonal antibodies (MAbs) neutralizing a broad range of primary isolates (PI) have been identified up to now. We have found that some MAbs with no neutralizing activities according to the "conventional" neutralization assay, involving phytohemagglutinin-stimulated peripheral blood mononuclear cells as targets, efficiently inhibit the replication of human immunodeficiency virus type 1 (HIV-1) PI in macrophages and immature dendritic cells (iDC). The mechanism of inhibition is distinct from the neutralization of infectivity occurring via Fab fragments and involves the interaction of the F portion with the Fc{gamma}Rs present on macrophages and iDC. We propose that, if such nonneutralizing inhibitory antibodies limit mucosal HIV transmission, they should be induced by vaccination.

* Corresponding author. Mailing address: EA 3770, Université Louis Pasteur, Institut de Virologie, 3 rue Koeberlé, F-67000 Strasbourg, France. Phone: 333 90 24 37 42. Fax: 333 90 24 37 23. E-mail: c.moog{at}viro-ulp.u-strasbg.fr.

Journal of Virology, June 2006, p. 6177-6181, Vol. 80, No. 12
0022-538X/06/$08.00+0     doi:10.1128/JVI.02625-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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