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Journal of Virology, June 2006, p. 5627-5630, Vol. 80, No. 11
0022-538X/06/$08.00+0     doi:10.1128/JVI.02448-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Batai and Ngari Viruses: M Segment Reassortment and Association with Severe Febrile Disease Outbreaks in East Africa

Thomas Briese,1* Brian Bird,2,3 Vishal Kapoor,1 Stuart T. Nichol,2 and W. Ian Lipkin1

Jerome L. and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, New York 10032,1 Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,2 School of Veterinary Medicine, University of California, Davis, California 956163

Received 21 November 2005/ Accepted 13 March 2006

Ngari virus is an orthobunyavirus recently recognized as a reassortant between Bunyamwera virus and an as yet unidentified M segment donor. Analysis of M segment sequences of Batai and Ilesha viruses revealed 95% deduced amino acid identity between Batai virus and Ngari virus. These findings suggest Batai virus as the donor of Ngari virus M segment sequence. Analysis of Batai virus-related African isolates identified UgMP-6830, isolated from mosquitoes in Uganda, as an isolate of Batai virus. KV-141, isolated during a febrile disease outbreak in Sudan, was identified as another isolate of Ngari virus, emphasizing a role of this reassortant virus in severe human illness throughout East Africa.

* Corresponding author. Mailing address: Jerome L. and Dawn Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia University, New York, NY 10032. Phone: (212) 342-9035. Fax: (212) 342-9044. E-mail: thomas.briese{at}columbia.edu.

Journal of Virology, June 2006, p. 5627-5630, Vol. 80, No. 11
0022-538X/06/$08.00+0     doi:10.1128/JVI.02448-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lambert, A. J., Lanciotti, R. S. (2009). Consensus Amplification and Novel Multiplex Sequencing Method for S Segment Species Identification of 47 Viruses of the Orthobunyavirus, Phlebovirus, and Nairovirus Genera of the Family Bunyaviridae. J. Clin. Microbiol. 47: 2398-2404 [Abstract] [Full Text]  


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