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Journal of Virology, May 2006, p. 5097-5099, Vol. 80, No. 10
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.10.5097-5099.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Immunoglobulin GM and KM Allotypes and Prevalence of Anti-LKM1 Autoantibodies in Patients with Hepatitis C Virus Infection

Paolo Muratori,1 Susan E. Sutherland,2 Luigi Muratori,1 Alessandro Granito,1 Marcello Guidi,1 Georges Pappas,1 Marco Lenzi,1 Francesco B. Bianchi,1 and Janardan P. Pandey3*

Department of Internal Medicine, Cardioangiology, and Hepatology, Alma Mater Studiorum-University of Bologna, Policlinico Sant'Orsola-Malpighi, Bologna, Italy,1 Research Institute, Mission Hospitals, Inc., Asheville, North Carolina,2 Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina3

Received 24 January 2006/ Accepted 28 February 2006

GM and KM allotypes—genetic markers of immunoglobulin (Ig) {gamma} and {kappa} chains, respectively—are associated with humoral immunity to several infection- and autoimmunity-related epitopes. We hypothesized that GM and KM allotypes contribute to the generation of autoantibodies to liver/kidney microsomal antigen 1 (LKM1) in hepatitis C virus (HCV)-infected persons. To test this hypothesis, we characterized 129 persons with persistent HCV infection for several GM and KM markers and for anti-LKM1 antibodies. The heterozygous GM 1,3,17 23 5,13,21 phenotype was significantly associated with the prevalence of anti-LKM1 antibodies (odds ratio, 5.13; P = 0.002), suggesting its involvement in this autoimmune phenomenon in HCV infection.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425-2230. Phone: (843) 792-4360. Fax: (843) 792-4882. E-mail: pandeyj{at}musc.edu.

Journal of Virology, May 2006, p. 5097-5099, Vol. 80, No. 10
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.10.5097-5099.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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