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Journal of Virology, May 2006, p. 5074-5077, Vol. 80, No. 10
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.10.5074-5077.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

Levi J. Yant,1,2 Thomas C. Friedrich,1 Randall C. Johnson,3 Gemma E. May,1 Nicholas J. Maness,1,2 Alissa M. Enz,1 Jeffrey D. Lifson,4 David H. O'Connor,1,2 Mary Carrington,3 and David I. Watkins1,2*

Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53715,1 Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, Madison, Wisconsin 53715,2 Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702,3 and AIDS Vaccine Program/Basic Research Program, Science Applications International Corporation-Fredrick, Frederick, Maryland 210724

Received 8 November 2005/ Accepted 1 February 2006

Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B*17 was associated with a 26-fold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17 was also enriched 1,000-fold in a group of animals that controlled viral replication. Even after accounting for this group, Mamu-B*17 was associated with an eightfold reduction in plasma virus concentrations (P < 0.001). Mamu-B*17-positive macaques could, therefore, facilitate our understanding of the correlates of viral control.

* Corresponding author. Mailing address: David Watkins, University of Wisconsin—Madison, 555 Science Drive, Madison, WI 53711. Phone: (608) 265-3380. Fax: (608) 265-8084. E-mail: watkins{at}primate.wisc.edu.

Journal of Virology, May 2006, p. 5074-5077, Vol. 80, No. 10
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.10.5074-5077.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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