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Journal of Virology, May 2006, p. 4868-4877, Vol. 80, No. 10
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.10.4868-4877.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparison of Simian Immunodeficiency Virus SIVagmVer Replication and CD4⁺ T-Cell Dynamics in Vervet and Sabaeus African Green Monkeys

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, Maryland 20892,¹ Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, Louisiana 70433,² Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Research East 113, 41 Avenue Louis Pasteur, Boston, Massachusetts 02115³

Received 20 January 2006/ Accepted 27 February 2006

The simian immunodeficiency viruses (SIV) naturally infect a wide range of African primates, including African green monkeys (AGM). Despite moderate to high levels of plasma viremia in naturally infected AGM, infection is not associated with immunodeficiency. We recently reported that SIVagmVer90 isolated from a naturally infected vervet AGM induced AIDS following experimental inoculation of pigtailed macaques. The goal of the present study was to evaluate the replication of this isolate in two species of AGM, sabaeus monkeys (Chlorocebus sabaeus) and vervets (C. pygerythrus). Inoculation of sabaeus AGM with SIVagmVer90 resulted in low and variable primary and set-point viremia (<10² to 10⁴ copies/ml). In contrast, inoculation of vervet AGM with either SIVagmVer90 or blood from a naturally infected vervet (Ver1) resulted in high primary viremia and moderate plateau levels, similar to the range seen in naturally infected vervets from this cohort. CD4⁺ T cells remained stable throughout infection, even in AGM with persistent high viremia. Despite the lack of measurable lymphadenopathy, infection was associated with an increased number of Ki-67⁺ T cells in lymph node biopsies, consistent with an early antiviral immune response. The preferential replication of SIVagmVer in vervet versus sabaeus AGM shows that it is critical to match AGM species and SIV strains for experimental models of natural SIV infection.

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