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Journal of Virology, January 2006, p. 541-544, Vol. 80, No. 1
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.1.541-544.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Gamma Interferon Primes Productive Human Immunodeficiency Virus Infection in Astrocytes

Deborah Carroll-Anzinger and Lena Al-Harthi*

Department of Immunology and Microbiology, Rush University Medical Center, Chicago, Illinois

Received 6 July 2005/ Accepted 8 October 2005

Considerable controversy exists over whether astrocytes can support human immunodeficiency virus (HIV) infection. We evaluated the impact of three cytokines critical to the development of HIV neuropathogenesis, gamma interferon (IFN-{gamma}), granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor alpha, on priming astrocytes for HIV infection. We demonstrate that IFN-{gamma} was the most potent in its ability to facilitate substantial productive HIV infection of an astroglioma cell line (U87MG) and human fetal astrocytes (HFA). The mechanism of IFN-{gamma}-mediated priming of HIV in HFA is unlikely to be at the level of up-regulation of receptors and coreceptors relevant to HIV entry. These data demonstrate that cytokine priming can alter HIV replication in astrocytes.

* Corresponding author. Mailing address: Rush University Medical Center, Department of Immunology/Microbiology, 1735 W. Harrison Street, 614 Cohn, Chicago, IL 60612. Phone: (312) 563-3220. Fax: (312) 942-5206. E-mail: lalharth{at}rush.edu.

Journal of Virology, January 2006, p. 541-544, Vol. 80, No. 1
0022-538X/06/$08.00+0     doi:10.1128/JVI.80.1.541-544.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sun, J., Zheng, J. H., Zhao, M., Lee, S., Goldstein, H. (2008). Increased In Vivo Activation of Microglia and Astrocytes in the Brains of Mice Transgenic for an Infectious R5 Human Immunodeficiency Virus Type 1 Provirus and for CD4-Specific Expression of Human Cyclin T1 in Response to Stimulation by Lipopolysaccharides. J. Virol. 82: 5562-5572 [Abstract] [Full Text]  
  • Carroll-Anzinger, D., Kumar, A., Adarichev, V., Kashanchi, F., Al-Harthi, L. (2007). Human Immunodeficiency Virus-Restricted Replication in Astrocytes and the Ability of Gamma Interferon To Modulate This Restriction Are Regulated by a Downstream Effector of the Wnt Signaling Pathway. J. Virol. 81: 5864-5871 [Abstract] [Full Text]  


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