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J Virol. 1971 November; 8(5): 708-715
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Integration of Simian Virus 40 Deoxyribonucleic Acid into the Deoxyribonucleic Acid of Primary Infected Chinese Hamster Cells

The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104

ABSTRACT

Simian virus 40 deoxyribonucleic acid (DNA) became associated in an alkaline-stable form with the DNA of Chinese hamster embryo cells at 15 to 20 hr post-infection, at the time when cell DNA synthesis and T antigen were induced. The integration process was not inhibited by D-arabinosyl cytosine and was only partially inhibited by cycloheximide.

¹ Present address: Department of Pathology, University of Colorado Medical Center, Denver, Colo.

² Recipient of American Cancer Society Faculty Research Award PRA-47 and Wistar Professor of Pathology, University of Pennsylvania.