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J Virol. 1971 November; 8(5): 656-660
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Inhibition of the Synthesis of Simian Virus 40 Antigens in Cells Preinfected with Yaba Tumor Virus ¹

Laboratory of Molecular Virology, Department of Microbiology, Southern Illinois University, Carbondale, Illinois 62901

ABSTRACT

The synthesis of tumor and viral antigens after infection of an established line of cynomolgus monkey kidney cells with simian virus 40 (SV40) was compared in cells previously infected with Yaba virus and in cells not preinfected. SV40 failed to induce synthesis of tumor or viral antigens in cells preinfected with Yaba virus. The inhibitory state in preinfected cells was shown to develop sequentially. Increase in the rate of deoxyribonucleic acid synthesis in the nuclei of preinfected cells occurred after infection with SV40. This rate of increase was significantly lower than that which occurred in SV40-infected cells which had not been preinfected. Cytosine arabinoside did not exert significant effect on the development of the inhibitory effect against SV40 in Yaba virus-infected cells.

² On leave from the National Institutes of Health, Tokyo, Japan.

¹ A preliminary account of this work has been presented previously (Y. Tsuchiya, T. Fenger, and H. Rouhandeh, Bacteriol. Proc., p. 85, 1971).