This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Freedman, M. L. Articles by Krisch, R. E. Search for Related Content PubMed PubMed Citation Articles by Freedman, M. L. Articles by Krisch, R. E.

Enlargement of Escherichia coli After Bacteriophage Infection II. Proposed Mechanism

^a Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois 60439

ABSTRACT

Division of Escherichia coli was stopped and mean cellular volume was increased after infection with T-even phage. This host cell enlargement was temperature-dependent, cyanide-sensitive, and stable in the presence of hypertonic medium. Enlargement ceased at about the same time that energy metabolism ceased. Initially, enlargement was accompanied by a decrease in mean cell density. Tritiated 2, 6-diaminopimelic acid was accumulated and incorporated into cold acid-insoluble material at the preinfection rate. These findings suggest that the effect on host cell size is only in part an osmotic phenomenon and that it also reflects continued growth of the surface of the infected cell in the absence of cell division.

¹ Present address: The University of Connecticut Health Center, Department of Oral Radiology, McCook Hospital, Hartford, Conn. 06112.

This article has been cited by other articles:

• Abedon, S. T., Hyman, P., Thomas, C. (2003). Experimental Examination of Bacteriophage Latent-Period Evolution as a Response to Bacterial Availability. Appl. Environ. Microbiol. 69: 7499-7506 [Abstract] [Full Text]  
• Miller, E. S., Kutter, E., Mosig, G., Arisaka, F., Kunisawa, T., Ruger, W. (2003). Bacteriophage T4 Genome. Microbiol. Mol. Biol. Rev. 67: 86-156 [Abstract] [Full Text]