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Mechanism of Oncogenic Transformation by Rous Sarcoma Virus II. Effect of Rifampin on Rous Sarcoma Virus Infection

^a Louis A. Wehle Virus Research Laboratory, Department of Microbiology, The University of Rochester School of Medicine and Dentistry, Rochester, New York 14620

ABSTRACT

Rifampin partially inhibits focus formation and virus production in chick embryo fibroblasts infected with Bryan high-titer Rous sarcoma (RAV-1) virus. This inhibition occurs with exposure to rifampin during a critical period between day 1 and day 2 after infection. This suggests that the drug does not affect formation of the provirus or its transcription or translation after the "fixation" step, but it seems to affect one or more events which take place before fixation and activation of virus production.

¹ Part of this work has been carried out by N. J. Richert, National Institutes of Health predoctoral trainee, in partial fulfillment of the requirement for a degree of Doctor of Philosophy and was presented at the 69th Annual Meeting of the American Society for Microbiology, Boston, Mass., 26 April-1 May, 1970.