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J Virol. 1971 July; 8(1): 1-6
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Effect of Inactivation by Hydroxylamine on Early Functions of Poliovirus

Karin Borgert, Klaus Koschel, Helmut Täuber and Eberhard Wecker

Institut für Virologie der Universität Würzburg, D8700 Würzburg, Germany

ABSTRACT

Evidence is presented that poliovirus particles with a single lethal hit by hydroxylamine do not induce in host cells either inhibition of cellular protein synthesis or viral ribonucleic acid (RNA) replication. The RNA of these viruses is not replicated even if the cells are simultaneously infected with both active and inactivated viruses. The damaged viral RNA seems to have lost both its template function and its function in the translation of normal viral proteins.


J Virol. 1971 July; 8(1): 1-6
Copyright © 1971 American Society for Microbiology. All Rights Reserved.




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J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1971 by the American Society for Microbiology. All rights reserved.