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Journal of Virology, May 2005, p. 5847-5849, Vol. 79, No. 9
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.9.5847-5849.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Pathological Prion Protein in the Tongues of Sheep Infected with Naturally Occurring Scrapie

Cristina Casalone, Cristiano Corona, Maria Ines Crescio, Francesca Martucci, Maria Mazza, Giuseppe Ru, Elena Bozzetta, Pier Luigi Acutis, and Maria Caramelli*

CEA, Italian Reference Laboratory for TSE, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Turin, Italy

Received 12 July 2004/ Accepted 1 December 2004

Tongue involvement by prion spreading was shown to be a common outcome after oral or intracranial experimental challenge with scrapie and transmissible mink encephalopathy sources in rodent models. It is also known that bovine spongiform encephalopathy, which is pathogenic for humans, is experimentally transmissible to sheep and can lead to a disease indistinguishable from scrapie. A recent European Food Safety Authority opinion recommended research into PrPsc accumulation in the tongues of ruminants. We report on the detection of PrPsc in the tongues of seven scrapie-infected sheep by immunohistochemistry and Western blotting.

* Corresponding author. Mailing address: CEA-IZS Piemonte, Liguria e Valle d'Aosta, Via Bologna, 148 Turin 10154, Italy. Phone: 39 (0) 11 2686296. Fax: 39 (0) 11 2686322. E-mail: cea{at}izsto.it.

Journal of Virology, May 2005, p. 5847-5849, Vol. 79, No. 9
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.9.5847-5849.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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