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Journal of Virology, April 2005, p. 5211-5214, Vol. 79, No. 8
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.8.5211-5214.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Weak Palindromic Consensus Sequences Are a Common Feature Found at the Integration Target Sites of Many Retroviruses

Laboratory of Molecular Technology,¹ AIDS Vaccine Program, Scientific Application International Corporation, National Cancer Institute at Frederick, Frederick,² Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland³

Received 2 September 2004/ Accepted 14 December 2004

Integration into the host genome is one of the hallmarks of the retroviral life cycle and is catalyzed by virus-encoded integrases. While integrase has strict sequence requirements for the viral DNA ends, target site sequences have been shown to be very diverse. We carefully examined a large number of integration target site sequences from several retroviruses, including human immunodeficiency virus type 1, simian immunodeficiency virus, murine leukemia virus, and avian sarcoma-leukosis virus, and found that a statistical palindromic consensus, centered on the virus-specific duplicated target site sequence, was a common feature at integration target sites for these retroviruses.

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