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Journal of Virology, April 2005, p. 4545-4549, Vol. 79, No. 7
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.7.4545-4549.2005

The pp38 Gene of Marek's Disease Virus (MDV) Is Necessary for Cytolytic Infection of B Cells and Maintenance of the Transformed State but Not for Cytolytic Infection of the Feather Follicle Epithelium and Horizontal Spread of MDV

I. M. Gimeno, R. L. Witter, H. D. Hunt, S. M. Reddy,{dagger} L. F. Lee, and R. F. Silva*

USDA-Agriculture Research Service, Avian Disease and Oncology Laboratory, East Lansing, Michigan

Received 4 October 2004/ Accepted 18 November 2004

Marek's disease virus has a unique phosphoprotein, pp38, which is suspected to play an important role in Marek's disease pathogenesis. The objective of the present study was to utilize a mutant virus lacking the pp38 gene (rMd5{Delta}pp38) to better characterize the biological function of pp38. This work shows that the pp38 gene is necessary to establish cytolytic infection in B cells but not in feather follicle epithelium, to produce an adequate level of latently infected T cells, and to maintain the transformed status in vivo.

* Corresponding author. Mailing address: USDA-Agriculture Research Service, Avian Disease and Oncology Laboratory, 3606 East Mount Hope Rd., East Lansing, MI 48823. Phone: (517) 337-6833. Fax: (517) 337-6776. E-mail: silvar{at}msu.edu.

{dagger} Present address: College of Veterinary Medicine, Texas A&M University, College Station, Tex.

Journal of Virology, April 2005, p. 4545-4549, Vol. 79, No. 7
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.7.4545-4549.2005




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