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Journal of Virology, April 2005, p. 3979-3986, Vol. 79, No. 7
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.7.3979-3986.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Insertional Polymorphisms of Endogenous Feline Leukemia Viruses

Alfred L. Roca,1* William G. Nash,2 Joan C. Menninger,1 William J. Murphy,1,3 and Stephen J. O'Brien4*

Laboratory of Genomic Diversity, Basic Research Program, SAIC-Frederick,1 Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland,4 H&W Cytogenetic Services, Inc., Lovettsville, Virginia,2 Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas3

Received 1 September 2004/ Accepted 10 December 2004

The number, chromosomal distribution, and insertional polymorphisms of endogenous feline leukemia viruses (enFeLVs) were determined in four domestic cats (Burmese, Egyptian Mau, Persian, and nonbreed) using fluorescent in situ hybridization and radiation hybrid mapping. Twenty-nine distinct enFeLV loci were detected across 12 of the 18 autosomes. Each cat carried enFeLV at only 9 to 16 of the loci, and many loci were heterozygous for presence of the provirus. Thus, an average of 19 autosomal copies of enFeLV were present per cat diploid genome. Only five of the autosomal enFeLV sites were present in all four cats, and at only one autosomal locus, B4q15, was enFeLV present in both homologues of all four cats. A single enFeLV occurred in the X chromosome of the Burmese cat, while three to five enFeLV proviruses occurred in each Y chromosome. The X chromosome and nine autosomal enFeLV loci were telomeric, suggesting that ectopic recombination between nonhomologous subtelomeres may contribute to enFeLV distribution. Since endogenous FeLVs may affect the infectiousness or pathogenicity of exogenous FeLVs, genomic variation in enFeLVs represents a candidate for genetic influences on FeLV leukemogenesis in cats.

* Corresponding author. Mailing address: Laboratory of Genomic Diversity, National Cancer Institute-Frederick, Building 560, Frederick, MD 21702-1201. Phone: (301) 846-1296. Fax: (301) 846-1686. E-mail for A. L. Roca: roca{at}ncifcrf.gov. E-mail for S. J. O'Brien: obrien{at}ncifcrf.gov

Journal of Virology, April 2005, p. 3979-3986, Vol. 79, No. 7
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.7.3979-3986.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pontius, J. U., Mullikin, J. C., Smith, D. R., Agencourt Sequencing Team, , Lindblad-Toh, K., Gnerre, S., Clamp, M., Chang, J., Stephens, R., Neelam, B., Volfovsky, N., Schaffer, A. A., Agarwala, R., Narfstrom, K., Murphy, W. J., Giger, U., Roca, A. L., Antunes, A., Menotti-Raymond, M., Yuhki, N., Pecon-Slattery, J., Johnson, W. E., Bourque, G., Tesler, G., NISC Comparative Sequencing Program, , O'Brien, S. J. (2007). Initial sequence and comparative analysis of the cat genome. Genome Res 17: 1675-1689 [Abstract] [Full Text]  


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