This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, R. T.
Right arrow Articles by Bresnahan, W. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, R. T.
Right arrow Articles by Bresnahan, W. A.

 Previous Article  |  Next Article 

Journal of Virology, March 2005, p. 3873-3877, Vol. 79, No. 6
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.6.3873-3877.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Human Cytomegalovirus Immediate-Early 2 Gene Expression Blocks Virus-Induced Beta Interferon Production

R. Travis Taylor{dagger} and Wade A. Bresnahan*

Department of Microbiology, University of Minnesota, Minneapolis, Minnesota

Received 12 August 2004/ Accepted 2 November 2004

The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-ß) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-ß during HCMV infection. IE86 also efficiently blocked the induction of IFN-ß following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-ß is not limited to HCMV infection, identifying IE2 as an IFN-ß antagonist.

* Corresponding author. Mailing address: Department of Microbiology, University of Minnesota, 1060 Mayo Building, MMC196, Minneapolis, MN 55455. Phone: (612) 626-5876. Fax: (612) 626-0623. E-mail: bresn013{at}umn.edu.

{dagger} Present address: Department of Microbiology, UT Southwestern Medical Center, Dallas, TX 75390.

Journal of Virology, March 2005, p. 3873-3877, Vol. 79, No. 6
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.6.3873-3877.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Krauss, S., Kaps, J., Czech, N., Paulus, C., Nevels, M. (2009). Physical Requirements and Functional Consequences of Complex Formation between the Cytomegalovirus IE1 Protein and Human STAT2. J. Virol. 83: 12854-12870 [Abstract] [Full Text]  
  • Iversen, A.-C., Steinkjer, B., Nilsen, N., Bohnhorst, J., Moen, S. H., Vik, R., Stephens, P., Thomas, D. W., Benedict, C. A., Espevik, T. (2009). A Proviral Role for CpG in Cytomegalovirus Infection. J. Immunol. 182: 5672-5681 [Abstract] [Full Text]  
  • Nitzsche, A., Paulus, C., Nevels, M. (2008). Temporal Dynamics of Cytomegalovirus Chromatin Assembly in Productively Infected Human Cells. J. Virol. 82: 11167-11180 [Abstract] [Full Text]  
  • Huh, Y. H., Kim, Y. E., Kim, E. T., Park, J. J., Song, M. J., Zhu, H., Hayward, G. S., Ahn, J.-H. (2008). Binding STAT2 by the Acidic Domain of Human Cytomegalovirus IE1 Promotes Viral Growth and Is Negatively Regulated by SUMO. J. Virol. 82: 10444-10454 [Abstract] [Full Text]  
  • Gealy, C., Humphreys, C., Dickinson, V., Stinski, M., Caswell, R. (2007). An activation-defective mutant of the human cytomegalovirus IE2p86 protein inhibits NF-{kappa}B-mediated stimulation of the human interleukin-6 promoter. J. Gen. Virol. 88: 2435-2440 [Abstract] [Full Text]  
  • Petrik, D. T., Schmitt, K. P., Stinski, M. F. (2007). The Autoregulatory and Transactivating Functions of the Human Cytomegalovirus IE86 Protein Use Independent Mechanisms for Promoter Binding. J. Virol. 81: 5807-5818 [Abstract] [Full Text]  
  • Montag, C., Wagner, J., Gruska, I., Hagemeier, C. (2006). Human Cytomegalovirus Blocks Tumor Necrosis Factor Alpha- and Interleukin-1{beta}-Mediated NF-{kappa}B Signaling. J. Virol. 80: 11686-11698 [Abstract] [Full Text]  
  • Perry, S. T., Compton, T. (2006). Kaposi's Sarcoma-Associated Herpesvirus Virions Inhibit Interferon Responses Induced by Envelope Glycoprotein gpK8.1. J. Virol. 80: 11105-11114 [Abstract] [Full Text]  
  • Taylor, R. T., Bresnahan, W. A. (2006). Human Cytomegalovirus IE86 Attenuates Virus- and Tumor Necrosis Factor Alpha-Induced NF{kappa}B-Dependent Gene Expression.. J. Virol. 80: 10763-10771 [Abstract] [Full Text]  
  • Valchanova, R. S., Picard-Maureau, M., Budt, M., Brune, W. (2006). Murine Cytomegalovirus m142 and m143 Are both Required To Block Protein Kinase R-Mediated Shutdown of Protein Synthesis.. J. Virol. 80: 10181-10190 [Abstract] [Full Text]  
  • Paulus, C., Krauss, S., Nevels, M. (2006). A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling. Proc. Natl. Acad. Sci. USA 103: 3840-3845 [Abstract] [Full Text]  
  • Taylor, R. T., Bresnahan, W. A. (2006). Human Cytomegalovirus Immediate-Early 2 Protein IE86 Blocks Virus-Induced Chemokine Expression. J. Virol. 80: 920-928 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»