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Journal of Virology, March 2005, p. 3851-3854, Vol. 79, No. 6
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.6.3851-3854.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Lambda Interferon Inhibits Hepatitis B and C Virus Replication{dagger}

Michael D. Robek,* Bryan S. Boyd, and Francis V. Chisari

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California

Received 6 September 2004/ Accepted 25 October 2004

Lambda interferon (IFN-{lambda}) induces an intracellular IFN-{alpha}/ß-like antiviral response through a receptor complex distinct from the IFN-{alpha}/ß receptor. We therefore determined the ability of IFN-{lambda} to inhibit hepatitis B virus (HBV) and hepatitis C virus (HCV) replication. IFN-{lambda} inhibits HBV replication in a differentiated murine hepatocyte cell line with kinetics and efficiency similar to IFN-{alpha}/ß and does not require the expression of IFN-{alpha}/ß or IFN-{gamma}. Furthermore, IFN-{lambda} blocked the replication of a subgenomic and a full-length genomic HCV replicon in human hepatocyte Huh7 cells. These results suggest the possibility that IFN-{lambda} may be therapeutically useful in the treatment of chronic HBV or HCV infection.

* Corresponding author. Present address: Department of Pathology, Yale University School of Medicine, P.O. Box 208023, 310 Cedar St. LH315A, New Haven, CT 06520-8023. Phone: (203) 785-6174. Fax: (203) 785-6127. E-mail: michael.robek{at}yale.edu.

{dagger} Paper no. 16793-MEM from The Scripps Research Institute.

Journal of Virology, March 2005, p. 3851-3854, Vol. 79, No. 6
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.6.3851-3854.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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