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Journal of Virology, March 2005, p. 3322-3328, Vol. 79, No. 6
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.6.3322-3328.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Modulation of the CD8+-T-Cell Response by CD4+ CD25+ Regulatory T Cells in Patients with Hepatitis B Virus Infection

Ornella Franzese,1,2 Patrick T. F. Kennedy,1 Adam J. Gehring,1 Jim Gotto,3 Roger Williams,1 Mala K. Maini,4 and Antonio Bertoletti1*

Institute of Hepatology, Royal Free Hospital and University College of London,1 Centre for Hepatology, Royal Free Hospital,3 Division of Infection and Immunity, Windeyer Institute of Medical Science, University College of London, London, United Kingdom,4 Dipartimento Neuroscienze, Universita di Roma "Tor Vergata," Rome, Italy2

Received 2 July 2004/ Accepted 23 October 2004

CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved hepatitis B virus (HBV) infection. We demonstrated that circulating CD4+ CD25+ T cells modulate the function and expansion of HBV-specific CD8+ cells ex vivo in all patients, regardless of whether they have chronic or resolved HBV infection. The possible role of CD4+ CD25+ T cells in the pathogenesis of chronic HBV infection is not supported by these data. However, these results might have implications for optimizing future immunotherapeutic approaches to HBV treatment.

* Corresponding author. Mailing address: Institute of Hepatology, University College London, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom. Phone: 44-20-7679 6517. Fax: 44-20-7679 0405. E-mail: a.bertoletti{at}ucl.ac.uk.

Journal of Virology, March 2005, p. 3322-3328, Vol. 79, No. 6
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.6.3322-3328.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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