This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lelièvre, J.-D.
Right arrow Articles by Estaquier, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lelièvre, J.-D.
Right arrow Articles by Estaquier, J.

 Previous Article  |  Next Article 

Journal of Virology, March 2005, p. 3195-3199, Vol. 79, No. 5
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.5.3195-3199.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interleukin 7 Increases Human Immunodeficiency Virus Type 1 LAI-Mediated Fas-Induced T-Cell Death

Jean-Daniel Lelièvre,1* Frédéric Petit,2 Damien Arnoult,2 Jean-Claude Ameisen,3 and Jérôme Estaquier2*

Laboratoire Inserm U421, Faculté de Médecine Henri Mondor, Créteil,1 INSERM EMI-U9922, Faculté Bichat-Claude Bernard,3 Unité Physiopathologie des Infections Lentivirales, Institut Pasteur, Paris, France2

Received 2 April 2004/ Accepted 18 October 2004

Fas-mediated T-cell death is known to occur during human immunodeficiency virus (HIV) infection. In this study, we found that HIV type 1 LAI (HIV-1LAI) primes CD8+ T cells from healthy donors for apoptosis, which occurs after Fas ligation. This effect is counteracted by a broad caspase inhibitor (zVAD-fmk). Fas-mediated cell death does not depend on CD8+ T-cell infection, because it occurred in the presence of reverse transcriptase inhibitors. However, purified CD8+ T cells are sensitive to Fas only in the presence of soluble CD4. Finally, we found that interleukin 7 (IL-7) increases Fas-mediated CD4+ and CD8+ T-cell death induced by HIV-1LAI. Since high levels of IL-7 are a marker of poor prognosis during HIV infection, our data suggest that enhancement of Fas-mediated T-cell death by HIV-1LAI and IL-7 is one of the mechanisms involved in progression to AIDS.

* Corresponding author. Mailing address for Jean-Daniel Lelièvre: Inserm U421, Faculté de Médecine Henri Mondor, 8 rue du général Sarrail, 94010 Créteil cedex, France. Phone: (33) 1 49 81 37 19. Fax: (33) 1 49 81 37 09. E-mail: lelievre{at}im3.inserm.fr. Mailing address for Jérôme Estaquier: Unité Physiopathologie des Infections Lentivirales, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris cedex 15, France. Phone: (33) 1 45 68 89 15. Fax: (33) 1 40 61 34 50. E-mail: jestaqui{at}pasteur.fr.

Journal of Virology, March 2005, p. 3195-3199, Vol. 79, No. 5
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.5.3195-3199.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rethi, B., Vivar, N., Sammicheli, S., Fluur, C., Ruffin, N., Atlas, A., Rajnavolgyi, E., Chiodi, F. (2008). Priming of T cells to Fas-mediated proliferative signals by interleukin-7. Blood 112: 1195-1204 [Abstract] [Full Text]  
  • Brown, K. N., Trichel, A., Barratt-Boyes, S. M. (2007). Parallel Loss of Myeloid and Plasmacytoid Dendritic Cells from Blood and Lymphoid Tissue in Simian AIDS. J. Immunol. 178: 6958-6967 [Abstract] [Full Text]  
  • Fluur, C., De Milito, A., Fry, T. J., Vivar, N., Eidsmo, L., Atlas, A., Federici, C., Matarrese, P., Logozzi, M., Rajnavolgyi, E., Mackall, C. L., Fais, S., Chiodi, F., Rethi, B. (2007). Potential Role for IL-7 in Fas-Mediated T Cell Apoptosis During HIV Infection. J. Immunol. 178: 5340-5350 [Abstract] [Full Text]  
  • Viollet, L., Monceaux, V., Petit, F., Fang, R. H. T., Cumont, M.-C., Hurtrel, B., Estaquier, J. (2006). Death of CD4+ T Cells from Lymph Nodes during Primary SIVmac251 Infection Predicts the Rate of AIDS Progression. J. Immunol. 177: 6685-6694 [Abstract] [Full Text]  
  • Muthukumar, A., Zhou, D., Paiardini, M., Barry, A. P., Cole, K. S., McClure, H. M., Staprans, S. I., Silvestri, G., Sodora, D. L. (2005). Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys. Blood 106: 3839-3845 [Abstract] [Full Text]  
  • Herbeuval, J.-P., Grivel, J.-C., Boasso, A., Hardy, A. W., Chougnet, C., Dolan, M. J., Yagita, H., Lifson, J. D., Shearer, G. M. (2005). CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis. Blood 106: 3524-3531 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»