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Journal of Virology, March 2005, p. 3169-3173, Vol. 79, No. 5
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.5.3169-3173.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Equine Herpesvirus 1 Utilizes a Novel Herpesvirus Entry Receptor

Arthur R. Frampton Jr.,1 William F. Goins,1 Justus B. Cohen,1 Jens von Einem,2 Nikolaus Osterrieder,2 Dennis J. O'Callaghan,3 and Joseph C. Glorioso1*

Department of Molecular Genetics and Biochemistry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania,1 Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York,2 Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana3

Received 17 September 2004/ Accepted 8 October 2004

The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans.

* Corresponding author. Mailing address: Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261. Phone: (412) 648-8105. Fax: (412) 624-8997. E-mail: glorioso{at}pitt.edu.

Journal of Virology, March 2005, p. 3169-3173, Vol. 79, No. 5
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.5.3169-3173.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Van de Walle, G. R., Peters, S. T., VanderVen, B. C., O'Callaghan, D. J., Osterrieder, N. (2008). Equine Herpesvirus 1 Entry via Endocytosis Is Facilitated by {alpha}V Integrins and an RSD Motif in Glycoprotein D. J. Virol. 82: 11859-11868 [Abstract] [Full Text]  
  • Frampton, A. R. Jr., Stolz, D. B., Uchida, H., Goins, W. F., Cohen, J. B., Glorioso, J. C. (2007). Equine Herpesvirus 1 Enters Cells by Two Different Pathways, and Infection Requires the Activation of the Cellular Kinase ROCK1. J. Virol. 81: 10879-10889 [Abstract] [Full Text]  
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