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Journal of Virology, February 2005, p. 1954-1957, Vol. 79, No. 3
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.3.1954-1957.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Vaccination with an Inactivated Virulent Feline Immunodeficiency Virus Engineered To Express High Levels of Env

Margaret J. Hosie,1* Dieter Klein,2 James M. Binley,3 Thomas H. Dunsford,1 Oswald Jarrett,1 James C. Neil,1 Elzbieta Knapp,2 Simone Giannecchini,4 Donatella Matteucci,4 Mauro Bendinelli,4 James A. Hoxie,5 and Brian J. Willett1

Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom,1 Department of Pathobiology, Institute of Virology, University of Veterinary Medicine, Vienna, Austria,2 The Scripps Research Institute, La Jolla, California,3 Retrovirus Center and Virology Section, Department of Experimental Pathology, University of Pisa, Pisa, Italy,4 Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania5

Received 11 June 2004/ Accepted 17 August 2004

An inactivated virus vaccine was prepared from a pathogenic isolate of feline immunodeficiency virus containing a mutation that eliminated an endocytic sorting signal in the envelope glycoprotein, increasing its expression on virions. Cats immunized with inactivated preparations of this modified virus exhibited strong titers of antibody to Env by enzyme-linked immunosorbent assay. Evidence of protection following challenge demonstrated the potential of this approach to lentiviral vaccination.

* Corresponding author. Mailing address: Retrovirus Research Laboratory, Institute of Comparative Medicine, University of Glasgow, Bearsden Rd., Glasgow G61 1QH, United Kingdom. Phone: 44 141 330 3274. Fax: 44 141 330 5602. E-mail: m.hosie{at}vet.gla.ac.uk.

Journal of Virology, February 2005, p. 1954-1957, Vol. 79, No. 3
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.3.1954-1957.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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Copyright © 2005 by the American Society for Microbiology. All rights reserved.