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Journal of Virology, February 2005, p. 1930-1933, Vol. 79, No. 3
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.3.1930-1933.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Anti-CXCR4 Monoclonal Antibodies Recognizing Overlapping Epitopes Differ Significantly in Their Ability To Inhibit Entry of Human Immunodeficiency Virus Type 1

Albert Einstein College of Medicine, Bronx,¹ Progenics Pharmaceuticals, Inc., Tarrytown, New York,³ Institut Cochin de Génétique Moléculaire, Paris, France²

Received 26 July 2004/ Accepted 22 September 2004

CXCR4 is one of two physiologically relevant human immunodeficiency type 1 (HIV-1) entry coreceptors. Studies of CXCR4 mutants have not clearly identified the determinants of coreceptor function and specificity. We therefore used a panel of monoclonal antibodies to further elucidate CXCR4 expression, structure, and function. Our findings show the existence of conformational subpopulations of CXCR4 that are in equilibrium on the cell surface but are not cell type specific as previously reported. HIV-1 X4 isolates can interact with multiple CXCR4 conformations in order to gain entry into target cells.

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