This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, C.
Right arrow Articles by Holmes, E. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, C.
Right arrow Articles by Holmes, E. C.

 Previous Article  |  Next Article 

Journal of Virology, December 2005, p. 15123-15130, Vol. 79, No. 24
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.24.15123-15130.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Clade Replacements in Dengue Virus Serotypes 1 and 3 Are Associated with Changing Serotype Prevalence{dagger}

Chunlin Zhang,1 Mammen P. Mammen Jr.,1 Piyawan Chinnawirotpisan,1 Chonticha Klungthong,1 Prinyada Rodpradit,1 Patama Monkongdee,1 Suchitra Nimmannitya,2 Siripen Kalayanarooj,2 and Edward C. Holmes3*

Department of Virology, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand,1 Queen Sirikit National Institute of Child Health, Bangkok, Thailand,2 Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, Pennsylvania 168023

Received 3 December 2004/ Accepted 20 September 2005

The evolution of dengue virus (DENV) is characterized by phylogenetic trees that have a strong temporal structure punctuated by dramatic changes in clade frequency. To determine the cause of these large-scale phylogenetic patterns, we examined the evolutionary history of DENV serotype 1 (DENV-1) and DENV-3 in Thailand, where gene sequence and epidemiological data are relatively abundant over a 30-year period. We found evidence for the turnover of viral clades in both serotypes, most notably in DENV-1, where a major clade replacement event took place in genotype I during the mid-1990s. Further, when this clade replacement event was placed in the context of changes in serotype prevalence in Thailand, a striking pattern emerged; an increase in DENV-1 clade diversity was associated with an increase in the abundance of this serotype and a concomitant decrease in DENV-4 prevalence, while clade replacement was associated with a decline in DENV-1 prevalence and a rise of DENV-4. We postulate that intraserotypic genetic diversification proceeds at times of relative serotype abundance and that replacement events can result from differential susceptibility to cross-reactive immune responses.


* Corresponding author. Mailing address: Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802. Phone: (814) 863-4689. Fax: (814) 865-9131. E-mail: ech15{at}psu.edu.

{dagger} Supplemental material for this article may be found at http://www.jvi.asm.org/.


Journal of Virology, December 2005, p. 15123-15130, Vol. 79, No. 24
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.24.15123-15130.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.




This article has been cited by other articles:

  • Shu, P.-Y., Su, C.-L., Liao, T.-L., Yang, C.-F., Chang, S.-F., Lin, C.-C., Chang, M.-C., Hu, H.-C., Huang, J.-H. (2009). Molecular Characterization of Dengue Viruses Imported Into Taiwan during 2003-2007: Geographic Distribution and Genotype Shift. Am J Trop Med Hyg 80: 1039-1046 [Abstract] [Full Text]  
  • Jarman, R. G., Holmes, E. C., Rodpradit, P., Klungthong, C., Gibbons, R. V., Nisalak, A., Rothman, A. L., Libraty, D. H., Ennis, F. A., Mammen, M. P. Jr., Endy, T. P. (2008). Microevolution of Dengue Viruses Circulating among Primary School Children in Kamphaeng Phet, Thailand. J. Virol. 82: 5494-5500 [Abstract] [Full Text]  
  • Nagao, Y., Koelle, K. (2008). Cozzarelli Prize Winner: Decreases in dengue transmission may act to increase the incidence of dengue hemorrhagic fever. Proc. Natl. Acad. Sci. USA 105: 2238-2243 [Abstract] [Full Text]  
  • Kalayanarooj, S., Rimal, H. S., Andjaparidze, A., Vatcharasaevee, V., Nisalak, A., Jarman, R. G., Chinnawirotpisan, P., Mammen, M. P., Holmes, E. C., Gibbons, R. V. (2007). Clinical Intervention and Molecular Characteristics of a Dengue Hemorrhagic Fever Outbreak in Timor Leste, 2005. Am J Trop Med Hyg 77: 534-537 [Abstract] [Full Text]  
  • XU, G., DONG, H., SHI, N., LIU, S., ZHOU, A., CHENG, Z., CHEN, G., LIU, J., FANG, T., ZHANG, H., GU, C., TAN, X., YE, J., XIE, S., CAO, G. (2007). AN OUTBREAK OF DENGUE VIRUS SEROTYPE 1 INFECTION IN CIXI, NINGBO, PEOPLE'S REPUBLIC OF CHINA, 2004, ASSOCIATED WITH A TRAVELER FROM THAILAND AND HIGH DENSITY OF AEDES ALBOPICTUS. Am J Trop Med Hyg 76: 1182-1188 [Abstract] [Full Text]  
  • Adams, B., Holmes, E. C., Zhang, C., Mammen, M. P. Jr, Nimmannitya, S., Kalayanarooj, S., Boots, M. (2006). Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok. Proc. Natl. Acad. Sci. USA 103: 14234-14239 [Abstract] [Full Text]  
  • Zhou, Y., Mammen, M. P. Jr, Klungthong, C., Chinnawirotpisan, P., Vaughn, D. W., Nimmannitya, S., Kalayanarooj, S., Holmes, E. C., Zhang, C. (2006). Comparative analysis reveals no consistent association between the secondary structure of the 3'-untranslated region of dengue viruses and disease syndrome. J. Gen. Virol. 87: 2595-2603 [Abstract] [Full Text]