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Journal of Virology, December 2005, p. 14640-14646, Vol. 79, No. 23
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.23.14640-14646.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Central Nervous System Pathology Caused by Autoreactive CD8+ T-Cell Clones following Virus Infection

Ikuo Tsunoda, Li-Qing Kuang, Mikako Kobayashi-Warren, and Robert S. Fujinami*

Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, Utah 84132

Received 1 July 2005/ Accepted 7 September 2005

Theiler's murine encephalomyelitis virus (TMEV) causes a demyelinating disease in infected mice which has similarities to multiple sclerosis. Spleen cells from TMEV-infected SJL/J mice stimulated with antigen-presenting cells infected with TMEV resulted in a population of autoreactive CD8+ cytotoxic T cells that kill uninfected syngeneic cells. We established CD8+ T cell clones that could kill both TMEV-infected and uninfected syngeneic targets, although infected target cells were killed more efficiently. The CD8+ T-cell clones produced gamma interferon when incubated with either infected or uninfected syngeneic target cells. Intracerebral injection of the clones into naïve mice induced degeneration, not only in the brain, but also in the spinal cord. This suggests that CD8+ Tc1 cells could play a pathogenic role in central nervous system inflammation.

* Corresponding author. Mailing address: Department of Neurology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, Utah 84132-2305. Phone: (801) 585-3305. Fax: (801) 585-3311. E-mail: Robert.Fujinami{at}hsc.utah.edu.

Journal of Virology, December 2005, p. 14640-14646, Vol. 79, No. 23
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.23.14640-14646.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tsunoda, I., Tanaka, T., Saijoh, Y., Fujinami, R. S. (2007). Targeting Inflammatory Demyelinating Lesions to Sites of Wallerian Degeneration. Am. J. Pathol. 171: 1563-1575 [Abstract] [Full Text]  


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