This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marsh, R. F.
Right arrow Articles by Bartz, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marsh, R. F.
Right arrow Articles by Bartz, J. C.

 Previous Article  |  Next Article 

Journal of Virology, November 2005, p. 13794-13796, Vol. 79, No. 21
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.21.13794-13796.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus)

Richard F. Marsh,1,{dagger} Anthony E. Kincaid,2 Richard A. Bessen,3 and Jason C. Bartz4*

Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison 53706,1 Department of Physical Therapy,2 Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska 68178,4 Department of Veterinary Molecular Biology, Montana State University, Bozeman, Montana 597183

Received 3 May 2005/ Accepted 10 August 2005

Chronic wasting disease (CWD) is an emerging prion disease of deer and elk. The risk of CWD transmission to humans following exposure to CWD-infected tissues is unknown. To assess the susceptibility of nonhuman primates to CWD, two squirrel monkeys were inoculated with brain tissue from a CWD-infected mule deer. The CWD-inoculated squirrel monkeys developed a progressive neurodegenerative disease and were euthanized at 31 and 34 months postinfection. Brain tissue from the CWD-infected squirrel monkeys contained the abnormal isoform of the prion protein, PrP-res, and displayed spongiform degeneration. This is the first reported transmission of CWD to primates.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178. Phone: (402) 280-1811. Fax: (402) 280-1875. E-mail: jbartz{at}creighton.edu.

{dagger} Deceased.

Journal of Virology, November 2005, p. 13794-13796, Vol. 79, No. 21
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.21.13794-13796.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Harrington, R. D., Baszler, T. V., O'Rourke, K. I., Schneider, D. A., Spraker, T. R., Liggitt, H. D., Knowles, D. P. (2008). A species barrier limits transmission of chronic wasting disease to mink (Mustela vison). J. Gen. Virol. 89: 1086-1096 [Abstract] [Full Text]  
  • Tamguney, G., Giles, K., Bouzamondo-Bernstein, E., Bosque, P. J., Miller, M. W., Safar, J., DeArmond, S. J., Prusiner, S. B. (2006). Transmission of elk and deer prions to transgenic mice.. J. Virol. 80: 9104-9114 [Abstract] [Full Text]  
  • Xie, Z., O'Rourke, K. I., Dong, Z., Jenny, A. L., Langenberg, J. A., Belay, E. D., Schonberger, L. B., Petersen, R. B., Zou, W., Kong, Q., Gambetti, P., Chen, S. G. (2006). Chronic Wasting Disease of Elk and Deer and Creutzfeldt-Jakob Disease: COMPARATIVE ANALYSIS OF THE SCRAPIE PRION PROTEIN. J. Biol. Chem. 281: 4199-4206 [Abstract] [Full Text]  
  • Schramm, P. T., Johnson, C. J., Mathews, N. E., McKenzie, D., Aiken, J. M., Pedersen, J. A. (2006). Potential Role of Soil in the Transmission of Prion Disease. Reviews in Mineralogy and Geochemistry 64: 135-152 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»