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Journal of Virology, October 2005, p. 13186-13189, Vol. 79, No. 20
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.20.13186-13189.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mucosal and Systemic Antibody Responses in Humans Infected with Simian Foamy Virus

HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,¹ Bureau of HIV/AIDS, STD, and TB, Centre for Infectious Disease Prevention and Control, Health Canada, Ottawa, Ontario, Canada²

Received 7 March 2005/ Accepted 26 July 2005

Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees. Overall, chimpanzee samples had higher anti-SFV IgG titers than humans. These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response.