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Journal of Virology, October 2005, p. 13173-13179, Vol. 79, No. 20
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.20.13173-13179.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Role for Herpesvirus Entry Mediator as the Receptor for Herpes Simplex Virus 1 Entry into Primary Human Trabecular Meshwork Cells

Vaibhav Tiwari,1 Christian Clement,2 Perry M. Scanlan,2 Devanand Kowlessur,1 Beatrice Y. J. T. Yue,1 and Deepak Shukla1,2*

Department of Ophthalmology and Visual Sciences,1 Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 606122

Received 13 May 2005/ Accepted 28 July 2005

The human eye is an important target for infection with herpes simplex virus 1 (HSV-1). Damage to cells forming the trabeculum of the eye by HSV-1 infection could contribute to the development of glaucoma, a major blinding disease. Primary cultures of human trabecular meshwork cells were used as an in vitro model to demonstrate the ability of HSV-1 to enter into and establish a productive infection of the trabeculum. Blocking of entry by anti-herpesvirus entry mediator (HVEM) antibody implicated HVEM as the major receptor for HSV-1 infection.

* Corresponding author. Mailing address: Department of Ophthalmology & Visual Sciences, Lions of Illinois Eye Research Institute, University of Illinois at Chicago, M/C 648, 1855 West Taylor Street, Chicago, IL 60612. Phone: (312) 355-0908. Fax: (312) 996-7773. E-mail: dshukla{at}uic.edu.

Journal of Virology, October 2005, p. 13173-13179, Vol. 79, No. 20
0022-538X/05/$08.00+0     doi:10.1128/JVI.79.20.13173-13179.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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